Thursday, December 30, 2004

Attempts to re-set my body clock (part 3)

Some success to report following the last post so now the work "Failed" is removed from the title.

In the last post I reported a single sleep block ending in a refreshing dream state sleep. I also felt more active and inclined to get on and do things after this and so there was some success, although I was now waking up 12 hours later than I should be.

Now, knowing that the human body has a natural tendency to a 25 hour unregulated diurnal cycle and that shifting the clock back is harder than shifting it forward, the plan from then on has been aimed at moving the wake up time forward an hour or two per day, starting from 26 December.

The aim was to peg my wake up time and determine my target go-to-sleep time. Having woken up on Christmas Day at 1700 and reckoning on needing 7 or 8 hours sleep my aim was to go to bed at about 1000 on the first day, and then day by day push this forward an hour or two until I was going to bed at a more normal time. I reckoned this might be possible in about 10-12 days.

I have had some unexpected fortune on the first day because I could not get to sleep until 1400 and ended up sleeping for another 9 hours instead of 7 (which was an excellent start really because I leapt forward 8 hours on the plan instead of 2 hours). So I woke up at 2300 which meant that my wake up time just needed to be forwarded by another 8 hours.

The next day I slept another 10 hours but this was split across two periods, one starting much earlier than planned (asleep 1300 awake refreshed at 1900) and the other 0300 to 0700 . Now this is the time I should be waking up!!! So in 2 days I was already on target. Could it be sustained?

Across the last 48 hours I have again slept in two periods. A 2 hour period in the late afternoon (my twighlight doze) and a 7 or 8 hour period, the first of which left me waking up at 0700 again but the last leaving me awake at 0330. This happened because yesterday I responded to a feeling of sleepiness at 2000 and decided to go to bed instead of going out as planned. I am beginning to think that my problems begin when I ignore a sleep signal in the early evenings.

I also now think that 7 hours sleep is fine in summer but in winter I should be aiming for 9 hours per night, to some extent mirroring the lengthening nights of winter. I was curious to learn from Coturnix that 2 periods of sleep per night is a normal pre-electric light sleep pattern, with the first sleep happening at sundown. Maybe I should not worry that I am currently getting my 9 hours sleep over 2 periods.

And here is another interesting observation which I have not mentioned before but which is interesting to note. Last Christmas when I was living in England I went out for a brisk walk with my son who complained bitterly at how cold it was outside. I was wearing fewer layers of clothes than he yet did not feel the cold at all. Months later, on March 1st in fact, I woke up at 0700 and felt frozen to the bone. I immediately leapt into the shower, got dressed and then was amazingly active. I then realised that my depression had lifted but only later called into question whether that morning was any colder than any other morning. My central heating system was working so the thermostat should make the temperature inside the same as yesterday. A call to a friend confirmed that my coldness was purely experiential to me as the outside temperature had certainly not changed. Conclusion? Well I believe that in winter I become cold tolerant. I therefore think that mother nature prevents me from experiencing the cold in winter time and takes steps to ensure that I do not become accidentally cold exposed. So I am awake at night and I am encouraged not to go out in the day*. (*Another feature of my so called depression is that I never seem to want to venture out unless I am forced to... a behavioural trait that is certainly a winter-time one and led by instinct rather than logic).

The interesting thing this morning was that 0630, soon after getting up I suddenly felt terribly cold. Frozen to the bone in fact! Now again this was experiential because I was not cold at 0530 and the temperature inside is well regulated. Am I coming out of the depression? An hour later the feeling had gone.

I certainly hope so! But I must be careful here. In England my depressions normally come on bad in December and lift in early March. Here in Finland it came on bad in November. If controlled by the hours of daylight (which I am inclined to believe with the science community that it is) then I ought to expect it to run through to until March or even April. But I have been using my light box recently (and at some odd and un-recommended times but with the aim of aiding the shift in sleep times). I wonder if that has had an impact?


Failed attempts to re-set my body clock (part 2)

Before recounting what has happened these last few days, Here is a recap of my normal summer wake-sleep cycle and my depressing winter wake-sleep cycle

In the summer time, my sleep-wake pattern is fairly normal. I guess it runs something like this

23.00 - 04.00 5 hours deep sleep
04.00 - 06.00 2 hours rem sleep (assuming it is the normal 2 hours)
06.00 - 15.00 9 hours wakefulness
15.00 - 16.00 1 hour afternooon dip (I leave the office for some fresh air and to wake up)
16.00 - 23.00 7 hours wakefulness ... gently tailing off before sleep


In the dead of winter, my natural pattern is shifted thus...

05.00 - 11.00 6 hours deep sleep. Wake unrefreshed. Never dreaming. Histamine flush?
11.00 - 16.00 5 hours awake but inefficient memory and cognition
16.00 - 18.00 2 hours Extreme sleepiness often with REM (cos I dream & wake refreshed)
18.00 - 22.00 4 hours moderate wakefulness
22.00 - 05.00 7 hours Wakefulness. I transit from wake to sleep without feeling sleepy

So in the winter I am getting two periods of sleep. My feeling is that sleep is delayed (for reasons unknown) so sleep starts about 5 or 6 hours later than normal. I have a feeling that I am woken by a chemical flush of histamines (because of the red flashes that appear on my face at this time). Whereas in the summer my bed clothes are often on the floor when I wake up, in winter they are as neat and tidy as when I went to bed. I concude that my sleep is active in the summer and that I dream and move about. I almost never wake dreaming on those winter mornings and I conclude that I am not getting my REM sleep. When sleep researchers wake people before they go into REM phase, the effect is to lower the cognitive ability of the individual. This is exactly how I feel.

My winter afternoon sleeps are brought on by the sunset and though short, they are refreshing and are often dream state sleeps if allowed to run their course. Thus, it seems to me that my normal summer time morning REM sleep is shifted to the afternoon with the consequence that I am then up all night.

OK. My effort just before Christmas did not enable me to delay sleep and move the sleep start time to midnight. I still was awake at midnight on 24 December. However, When I did get to sleep eventually at 5am I did sleep (not surprisingly perhaps) for 12 hours waking up at 5pm on Christmas Day. The great thing was that I had a long sleep and woke up dreaming, and feeling like I had had a good night's sleep. I had managed to join up the early morning and late afternoon sleeps into a single sleep period starting with a deep sleep and ending ina REM sleep. The only problem was that this sleep was ending about 12 hours later than it should!









Friday, December 24, 2004

Failed attempts to re-set my body clock (part 1)

Over the past few days I have been doing my best (a) to try to go to bed at a normal time (even though I am awake) and (b) trying not to sleep in the mornings. The result is that I feel awful!!!
I have been succeeding in not sleeping in the day and utterly failing to sleep at night. You would think that the sleep deprivation would enable the catch-up mechanism to fall into place so that night sleep can take place. In my case at least, it does not.

I found an interesting link about sleep and the circadian rhythm

http://www.abcbodybuilding.com/magazine03/analysisofsleep.htm

It includes some research by a Dr. Wozniak (whose work I will try and follow up on) and a recommendation for people with DSPS which is not unlike the others I have read. Maybe I should re-attempt using my light box to shift my sleep pattern bit by bit instead. But I get the impression that I need to freewheel first and get some proper sleep. Free-wheeling (sleeping as and when I needed it) was what I was doing after my rhythm broke down this year. Although it did not fit well with my university studies and I was not fully functional, at least I did not feel like I feel now... totally shattered!!



Delayed Sleep Phase Syndrome OR The Man with Two Brains

After a particularly stressful period in my life back in 1996 I started to develop problems that my doctor had labeled as depression. I would find myself being unable to sleep at night, having problems getting up in the mornings, and forgetting even the first names of work colleagues I had worked with for years. Only after several years did I notice there was a seasonal overlay to these problems. They tend to happen most in the winter, with some winters being worse than others, for reasons that are still not clear. And at the same time as I latched on to SAD (Seasonal Affective Disorder) and started experimenting with Light Therapy I was also diagnosed as having Auto-immune thyroid disease and low thyroid function. Treatments for both were mildly helpful, but the problem persisted. My doctor continued prescribing antidepressants even though after about 8 years (8 years!) I decided their effect was also, in fact, marginal.

Then about a year ago I learned of a condition that actually described my problem quite well. Delayed Sleep Phase Syndrome, or DSPS. In DSPS, people seem to have the onset of sleep delayed until 3 or 4 in the morning. A period of sleep then follows, which in my case is usually about 7 hours, so I typically might wake at about 11. But this sleep is not refreshing at all and it might take another hour before I can really get out of bed and get moving. When I visit the bathroom I am met in the mirror with a red, blotchy face, especially around the nose and eyes. I now suspect that this is caused by histamine, a hormone that plays a role in promoting wakefulness.

In normal people, in the last 2 hours of sleep, cortisol levels rise markedly and this period is also associated with REM sleep and dreaming, functions that are thought to promote organization of knowledge and memories and thoughts... i.e. higher brain functions. People deprived of REM sleep eventually become disorganized and dis-oriented, so REM sleep is considered to be very important. In most people, a 7 or 8 hour sleep period is followed by a period of activity during the day, with a progressive slowing down towards the end of the day, followed of course by the start of the next sleep period.

In people with DSPS, the period of intense wakefulness happens at night and the sleep period is not followed immediately by a period of intense activity.

This describes me quite well. In fact I am physically awake at 11 am, but mentally still asleep. At about 4pm (say) as daylight begins to fade, I can get very tired and sleepy, but of course sleep is not always possible, especially if at work. Rest is about as much as you can do. If I do get the opportunity to sleep it is usually a short sleep of perhaps one or 2 hours, but is incredibly refreshing. I wake up and finally have the energy and motivation to do things that I have been lacking all day. Unfortunately the energy boost is short lived so by midnight, physical exhaustion is back, but mental activity remains high until 4 or 5 in the morning.

What is going on here? Well, I have not been able to get a proper diagnosis or help but here is what I think is happening.

My feeling is that, when I am in this DSPS condition, I am not getting the 2 hours of REM sleep and my cortisol levels are low in the morning instead of being high. This means I have a depressed mental ability for most of the day. So although my lower brain is working and controlling my limbs and my physical being and I am walking around with the rest of the world, my higher brain is in fact only just about ticking over. It might just as well be fully asleep sometimes, because in the nadir of this condition I am mentally capable of nothing in the mornings or afternoons. In the late evening my lower brain is winding down my physical body, but my higher brain is only just waking up. Hence I am the main with two brains, each running on a different bio-rhythm. It is no wonder that I feel like I am only half my normal self at this time!

Because I get the boost in energy levels in the early evening, I believe that I am getting my circadian boost of cortisol from about 7pm, reaching a peak at about midnight. I very often am physically exhausted at this time, being incapable of any physical activity, yet totally unable to sleep. The mind is too active. And I believe that it is primarily the action of histamine that is waking me up in the mornings, judging by the bright red blotches on my face that will go away as the day progresses.

Now there is a family connection here. My mother, in her later life, stopped working and would often be asleep until late morning and describer herself as feeling pretty useless. Yet my father, who used to work at nights, would come home to discover that she had been sitting up all night, intensely listening to the radio. She also had other problems which fortunately I do not have, but I do think that there is an inherited characteristic here. Which leads to an interesting question. Debilitating as this condition is to the suffer, why has it survived? Does it confer a biological advantage? And is the reason that this tends to come on the winter somehow significant? I believe it is, and here is why.

The life we lead today is nothing like the life our ancestors led. It is their lifestyle needs that shaped their biology and in particular, gene characteristics that conferred a biological advantage. So what can possibly be so biologically advantageous about DSPS? Well actually, I think it is quite obvious.

One of the most important problems for our ancestors that migrated over millennia out of Africa to the northern and southern hemispheres would have been how to survive those long winter nights. Hypothermia is a killer even today. It would have been a major killer too for our ancestors. At night, when we are asleep and our body temperature drops and we lose consciousness during sleep. If we get too cold, we could easily die. So being awake and keeping that body temperature up, whether by keeping a fire going or just by being awake and being active, might be the difference between life and death. As hunter gathers, the human population in winter time has no need to be particularly active. Hunting is difficult and energy consuming. Better to live on those starchy foods put aside for the winter (is this sounding familiar?) and conserve energy by being relatively inactive. No need for much cunning in the wintertime (a higher brain function). And what better time to sleep than as the sun is coming up and temperatures will again be rising and not falling. So I am living out in this modern world, a pattern of behaviour that kept my ancestors alive but makes my life as IT Manager quite hellish in winter.

It is interesting to ponder why "depression" is so closely related to "stress". Why on earth did such a situation arise, and what possible benefit could it be to the species. My condition almost certainly arose after a very stressful life event, as indeed was the case with my mother. Perhaps the evolutionary story above is the clue. The stress of winter survival would certainly be a real stress for our ancestors and its onset could have triggered this potentially life saving condition. Its just that our bodies are driving by chemical signals and there is not much to distinguish psychological stressors from physical ones.

In due course, we may evolve out of this situation... but that is little comfort for me today.






Wednesday, December 22, 2004

Welcome to my blog

OK

Welcome to my blogg. Thanks to R for getting me started on this. We shall see whether I can keep the thing going and have enough to say that doesn't make my reader want to fall asleep in seconds flat.

This week has been perhaps both the least yet in some ways the most productive of my time here in Finland.

On the downside I have stopped struggling with this stupid bio-rhythm disorder of mine. This keeps me wide awake all night until about 0500. Then I fall fast asleep from 0500 until about 1300 (after which I wake up feeling as though I have not in fact slept at all). I always wake with bright red blotches on my face which I think is a sign that a histamine shower has woken me. But then I am physically awake from 1300 but mentally half asleep until I wake up properly at about 1900, sometimes (but not always) with a productive 1 hour nap anytime between 4pm and 7pm. This sllep-wake pattern kicked in when my classes had stopped for 4 weeks. When classes resumed I tried keeping to normal time for about 4 or 5 days days during which time I managed with just about 11 hours sleep in total. Of course this was unsustainable and I collapsed in total exhaustion on the Friday afternoon. So there will be no more formal classes in the university for me until I can get back into a more sustainable rhythm.

On the upside, I have been doing some private study with some good outcome. But more to the point I have just about doubled the number of new friends I have made here in this little Finnish town where I live. I have already made some good friends here and elsewhere in Finland, and these new people I think I will become good friends because we share so much in common. The similarities are very strange.. almost spooky. Unfortunately two of these new friends are having a torrid time right now in their personal lives. Both are experiencing or have experienced recently the stress of divorce and family disharmony. I am especially worried about P who was in tears this evening. She is trying to cope and clearly manages to put on a brave face when she needs to (as I saw with one of her sons tonight) but...when he was gone she almost collapsed from the strain of it all. On top of everything she has lost her voice so everything is communicated in writing. We hardly "spoke" at all this evening because she was so engrossed in family matters, and they are clearly wearing her down.

I know hardly anything of her problems and I must rely on E. (who has problems of his own) to take care of P... but she needs him right now and I hope that he can provide her with the support she needs. He is a wise soul and I am sure she is right to trust him. I know she knows that I would like to help, but right now it would not help for her to even try to explain to me what is going on. I know she is not sleeping, and it shows. I fear for her terribly. I think this woman will be in hospital from sheer exhaustion before too long. I hope she is strong enough to cope the future whether or not that happens.

So I ought to be feeling elated about these new friendships but in fact I am rather fearful for them. And as for my other friend R, I know he is having problems of his own right now and I worry a little too about him. But he assures me that all is going to be OK and that he can at least share his troubles with a friend who understands.

As you who follow this bogg will come to realise, I am a born worrier! I worry about anything and everything. But it means that I care.

I hope you will find my observations about life in two different european cultures to be of interest.

Sauna-Ukko